Institute of Bone and Joint Research, The Kolling Institute, Northern Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2065, Australia. Musculoskeletal Research Group, School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia. Musculoskeletal Australia, Melbourne, VIC 3185, Australia. Westmead Applied Research Centre and Westmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2145, Australia. Westmead Department of Cardiology, Westmead Hospital, Sydney, NSW 2145, Australia. Health Economics and Process Evaluation, The George Institute for Global Health, University of New South Wales Sydney, Sydney, NSW 2042, Australia. Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia. School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia.